Recent studies suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), like other coronaviruses, hijacks various host cell machinery such as autophagy for replication and ...
A cellular recycling system called CMA was found to be impaired in ALS motor neurons. Reduced CMA activity was linked to TDP-43 protein clumps, a hallmark of most ALS cases. Boosting CMA may be a ...
Neurodegeneration in brain cells may be happening when the natural cellular cleaning process malfunctions due to falling levels of a niacin-related coenzyme and leaves cells starved of energy, new ...
Scientists from Brown University say they have demonstrated a novel method for stimulating autophagy. In a study (“Nuclear Export Inhibition Enhances HLH-30/TFEB Activity, Autophagy, and Lifespan”), ...
A feature of pancreatic cancer cells' surroundings determines whether they grow fast or become resistant to chemotherapy, a new study shows. The ability of these cancer cells to adapt quickly and ...
Four genetic variants associated with autophagy are linked to increased CLL risk, providing insights into disease biology and potential future screening efforts. The study confirmed associations ...
MOUNTAINEER-03: Phase 3 study of tucatinib, trastuzumab, and mFOLFOX6 as first-line treatment in HER2+ metastatic colorectal cancer—Trial in progress. ONCX-NAV-G201: A phase 2 basket study of ...
Investigators at Sanford Burnham Prebys Medical Discovery Institute (SBP) say they have begun the first analysis of autophagy in a living animal as it ages. Autophagy is the normal physiological ...
Phenotypic differences in tumor-associated macrophages between metastatic and primary sites of clear cell renal cell carcinoma. This is an ASCO Meeting Abstract from the 2018 ASCO-SITC Clinical Immuno ...
A new study sheds light on how autophagy, the body’s process for removing damaged cell parts, when impaired, can play a role in causing heart failure. The research team led by Dr. E. Dale Abel, chair ...
The ability of plants to grow faster and stronger is traced to autophagy, along with key enzymes and proteins such as AFR7, ...
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