The firm will evaluate the combination therapy in 80 patients with germline BRCA1/2-mutated HER2-negative locally advanced or metastatic breast cancer.

Accuracy and Surgical Impact of Magnetic Resonance Imaging in Breast Cancer Staging: Systematic Review and Meta-Analysis in Detection of Multifocal and Multicentric Cancer Among the most promising ...

DURHAM, N.C. -- A breast cancer gene's newly discovered role in repairing damaged DNA may help explain why women who inherit a mutated copy of the gene are at increased risk for developing both breast ...

A new study funded by Cancer Research UK has mapped out some of the earliest changes that occur in seemingly healthy breast tissue long before any tumors appear, which could have significant ...

A pathway helping the breast cancer protein BRCA1 repair damaged DNA has been identified by University of Queensland researchers in a study that will inform future targeted therapies. Professor Robert ...

Correlation between overall survival and other endpoints in clinical trials of second-line chemotherapy for patients with advanced gastric cancer. Customization of treatment for patients with ...

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...

PARP inhibitors (PARPi) leverage synthetic lethality in BRCA-deficient cancers, yet intrinsic resistance limits therapeutic benefit. Through functional proteomics, this study uncovers that PARPi ...

T cell lineage maturation is a highly regulated process requiring intact DNA repair capacity 1,2. BRCA1 (breast cancer 1, early onset) is a tumor suppressor that probably has a DNA repair function.

One in four Indian breast cancer patients carries an inherited genetic variant linked to cancer risk, with the majority of these variants occurring outside the well-known BRCA1 and BRCA2 genes, a new ...