REISMAN, Zuelzer and Mitani 1 described polyploidy and endoreduplication of chromosomes in a patient being treated for acute leukemia. They ascribed these abnormalities to a primary chromosomal ...

c-Jun N-terminal kinase (JNK) is activated by diverse cell stimuli, including stress, growth factors, and cytokines. Traditionally, activation of JNK by stress treatment is thought to induce cell ...

The Fbw7/hCDC4 protein is the substrate specificity component of an Skp1–Cullin-F–Box ubiquitin ligase complex. Lesions in the Fbw7 gene have been observed in a large list of cancers (Moberg et al., ...

The wide variety of congenital anomalies often accompanying constitutional aplastic anemia has led to its recognition as a distinctive syndrome. Congenital malformations have been the outstanding ...