EurekAlert!

Class II PI3K lipid kinase: Structure of novel drug target resolved

Lipid kinases are among the promising targets of new classes of drugs, due mainly to class I PI3Kα, which plays a crucial role in carcinogenesis and metastasis. This enzyme is hyperactive in 30-40% of ...
Science Daily

After more than 20 years, scientists have solved the full-length structure of a Janus Kinase

More than two decades of effort went into a project that has now revealed the structure of a crucial signaling molecule, opening the door to new and better drugs for some cancers. For more than 20 ...
sciencex

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1

A publication from Acta Pharmaceutica Sinica B discusses the structure-based development of potent and selective type-II kinase inhibitors of RIPK1. Receptor-interacting serine/threonine-protein ...
Phys.org

Kinase enzymes exist throughout tree of life—those found in bacteria may be vulnerable targets for new antibiotics

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...
EurekAlert!

After more than 20 years, scientists have solved the full-length structure of a Janus Kinase

The breakthrough came on molecular biologist Christopher Garcia’s birthday. For more than 20 years, his team and others around the world had been chasing an elusive quarry – the 3D structure of a ...