Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by ...

From the time we are conceived and through old age, genetic mutations accumulate in all our tissues, eluding the body’s typically efficient DNA repair machinery and potentially affecting our health ...

DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have been linked to cancer, particularly colorectal ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

University of Pittsburgh researchers have shown for the first time how Merkel cell polyomavirus (MCV), which causes an aggressive skin cancer called Merkel cell carcinoma, initiates DNA replication in ...

DNA replication is one of life’s most precise and essential processes, ensuring genetic information is faithfully passed from cell to cell and generation to generation. This remarkable molecular ...

University of Utah researchers have found that host sex and genetics can influence how viruses evolve, potentially creating 'evolutionary accelerators' that make pathogens more virulent. The study, ...

Researchers were aiming to find a genetic solution to a rare and devastating disease but were not able to identify one. However, in the process they ...