More than 90% of people with Down syndrome (DS) are diagnosed with Alzheimer’s disease (AD) by ages 55–60. However, it remains unknown whether there is a difference in the structure of amyloid-β (Aβ) ...

Chemists have determined the structure of the fuzzy coat that surrounds tau proteins. Learning more about this structure could help scientists find ways to block tau from forming tangles in the brains ...

In recent years, support has grown for the idea that the same aggregating protein can fold up into different toxic shapes, giving rise to distinct neurodegenerative diseases. Now, in the August 29 ...

In another win for cryo-electron microscopy, researchers led by David Eisenberg at the University of California, Los Angeles, have solved the structure of a 10-residue tau segment containing the famed ...

One of the hallmarks of Alzheimer’s disease is the clumping of proteins called Tau, which form tangled fibrils in the brain. The more severe the clumping, the more advanced the disease is. The Tau ...

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Tau misfolding into β-sheet-rich filaments and subsequent recruitment of monomeric tau are central to Alzheimer's disease (AD) pathogenesis. While cryo-EM has resolved the conformation of the AD tau ...

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease ...

DALLAS - Oct.28, 2016 - The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and ...