PSC-derived cells can reverse type 1 diabetes in mice and may overcome some of the hurdles faced by existing stem cell ...

Mouse islet isolation from pancreas is a commonly used technique for diabetic investigations. A classical procedure includes three steps: collagenase perfusion, pancreas digestion and islet ...

The currently approved islet-transplant method infuses islets into a vein in the liver. This invasive procedure requires the long-term use of immune-suppressing drugs to prevent islet rejection, ...

Detailed characterization of human pancreatic islets is key to elucidate the pathophysiology of all forms of diabetes mellitus, including its most common form known as type 2 diabetes (T2D). However, ...

We report on a patient with type 1 diabetes mellitus, diagnosed at 16 years of age, in whom widespread amyloid deposits developed many years later in transplanted human islets. The islets were ...