One of the biggest challenges in cancer research is understanding why some tumor cells become especially aggressive, invasive and resistant to treatment. Scientists have increasingly linked these ...

(A) We created unique cells with double the usual number of chromosomes to investigate the relationship between polyploidy and DNA damage.(B) After treatment with the anti-cancer drug cisplatin, ...

Cancer cells that accumulate extra copies of their entire chromosome set can start behaving like immune cells, swallowing their neighbors and migrating through tissue to seed tumors in distant organs.

Polyploidy is a state where a cell contains more copies of the genetic material than the usual "diploid" cell, which contains two copies. Polyploidy often occurs in human diseases and cancers, and its ...

Confocal microscopy is performed with nuclear reporters and stains, nuclear segmentation with ilastik is conducted, and a machine learning method is used to classify the ploidy of each nucleus. Colors ...