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1. Target Cells Also called: Codocytes Appearance Look like a bull’s-eye / shooting target Dark center, surrounded by a clear ring, then a dark outer rim Thin RBC with increased surface area Why do they form? Excess cell membrane compared to hemoglobin Reduced hemoglobin content or altered lipid composition Seen in Thalassemia (very common) Liver disease Iron deficiency anemia Hemoglobinopathies (HbC, HbS) Post-splenectomy Lab & Exam Points ⭐ Common in microcytic anemias Often increased after sp
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