Mrinal Barua | Doctor | Nutrition | Metabolism on Instagram: "Increased conversion of glucose to fructose by the polyol pathway contributes to cataract formation mainly through osmotic and oxidative stress. In hyperglycemic conditions, excess glucose is metabolized to sorbitol, which accumulates in lens cells due to its poor membrane permeability. This causes water influx, cell swelling, and disruption of lens fiber organization, leading to opacity. Simultaneously, the pathway consumes NADPH, re